Table 1.
Top ten TFs controlling the expression of LA- and NL-related genes
| TF | Description | Number of targets | FDR | |
|---|---|---|---|---|
| TFs regulating LA-related genes | EHF | ETS Homologous Factor | 32 | 8.18E-11 |
| KLF5 | Kruppel Like Factor 5 | 30 | 1.23E-9 | |
| ZBTB7C | Zinc Finger And BTB Domain Containing 7C | 28 | 2.16E-8 | |
| GRHL2 | Grainyhead Like Transcription Factor 2 | 27 | 7.86E-8 | |
| ELF3 | E74 Like ETS Transcription Factor 3 | 26 | 2.95E-7 | |
| TFCP2L1 | Transcription Factor CP2 Like 1 | 23 | 2.0E-5 | |
| PAX9 | Paired Box 9 | 22 | 5.33E-5 | |
| E2F8 | E2F Transcription Factor 8 | 22 | 5.33E-5 | |
| IRF6 | Interferon Regulatory Factor 6 | 22 | 5.33E-5 | |
| OVOL1 | Ovo Like Transcriptional Repressor 1 | 21 | 1.41E-4 | |
| TFs regulating NL-related genes | BCL6B | BCL6B Transcription Repressor | 58 | 5.88E-29 |
| SOX18 | SRY-Box Transcription Factor 18 | 58 | 5.88E-29 | |
| MEOX1 | Mesenchyme Homeobox 1 | 54 | 1.38E-25 | |
| SOX7 | SRY-Box Transcription Factor 7 | 51 | 7.09E-23 | |
| EPAS1 | Endothelial PAS Domain Protein 1 | 44 | 3.26E-17 | |
| SOX17 | SRY-Box Transcription Factor 17 | 42 | 8.58E-16 | |
| MEOX2 | Mesenchyme Homeobox 2 | 41 | 3.77E-15 | |
| TCF21 | Transcription Factor 21 | 41 | 4.2E-15 | |
| ERG | ETS Transcription Factor ERG | 40 | 1.86E-14 | |
| EBF1 | EBF Transcription Factor 1 | 36 | 1.58E-11 |