Table 3.

Associations of BMI category at age 46 and BMI history with Bray Curtis, unweighted UniFrac, and weighted UniFrac distance matrices using MiKRAT models (n=563)

	Beta diversity measure
	Bray-Curtis	Unweighted Unifrac	Weighted Unifrac	Omnibus
BMI Category	P-Value†	P-Value†	P-Value†	P-Value†
Obese vs. normal BMI*	0.0002	0.001	0.01	0.002
Overweight vs. normal BMI*	0.79	0.80	0.92	0.96
BMI History
History 4 vs. 1*	0.41	0.15	0.48	0.45
History 3 vs. 1*	0.16	0.13	0.18	0.34
History 2 vs. 1*	0.26	0.21	0.20	0.39

^*MiKRAT models adjusted for exact age, sex, and smoking status (never, former, current or missing), and BMI at age 46 (for history models only)

^†For statistically significant p-values (<0.05), after repeating the MiRKAT models with 10,000 permutations they remained statistically significant under the empirical null distribution of the test statistic