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. Author manuscript; available in PMC: 2021 Nov 6.
Published in final edited form as: J Mol Biol. 2020 Oct 5;432(22):5938–5950. doi: 10.1016/j.jmb.2020.09.013

Figure 6: Non-canonical conformation of the CC′ loop of BTNL2.

Figure 6:

A. Lowest energy 10 structures of BTNL2 are shown in cartoon (cyan). Inset illustrates the rigid conformation of the CC′ loop observed in all the structures. For comparison, the variability in conformation for the C′D loop is shown. B. Pro44 (sticks, blue) on the CC′ loop potentially forms CH-π interaction with Trp97 (sticks, cyan) present on the F strand. Similarly, Tyr40 and Pro47 on the CC′ loop also interact in a similar fashion to stabilize and maintain the rigid non-canonical conformation of the CC′ loop. C. Potential hydrogen bond between Tyr40 and Ser42 is shown. This main-chain to main-chain H bond helps supplement the non-canonical CC′ loop conformation by lifting up the loop and causing it to peel away from the sheet surface.