Table 3:
Longitudinal associations of LDL metrics, separate models, with VMS frequency
| LDL-C β (SE) |
Total LDL-Pe β (SE) |
Intermediate LDL-Pe β (SE) |
Large LDL-Pe β (SE) |
Small LDL-Pe β (SE) |
LDL-Sizee β (SE) |
|
|---|---|---|---|---|---|---|
| Model 1a | ||||||
| Infrequent VMS | 2.77 (1.52) | 0.03 (0.01) | 0.07 (0.04) | −0.04 (0.04) | 0.04(0.05) | 0.001 (0.002) |
| Frequent VMS | 6.30 (1.82)d | 0.05 (0.02)d | 0.09 (0.05)d | 0.03 (0.05) | 0.08 (0.06) | −0.001 (0.002) |
| Trend p | 0.0005 | 0.003 | 0.03 | 0.78 | 0.13 | 0.76 |
| Model 2b | ||||||
| Infrequent VMS | 2.09 (1.43) | 0.02 (0.01) | 0.06 (0.04) | −0.05 (0.05) | 0.05 (0.05) | 0.00004 (0.002) |
| Frequent VMS | 3.58 (1.77)d | 0.03 (0.02) | 0.09 (0.05) | −0.02 (0.06) | 0.07 (0.06) | −0.003 (0.002) |
| Trend p | 0.04 | 0.06 | 0.04 | 0.55 | 0.20 | 0.18 |
| Model 3c | ||||||
| Infrequent VMS | 1.59 (1.42) | 0.02 (0.01) | 0.05 (0.04) | −0.05 (0.05) | 0.05 (0.05) | −0.0001 (0.002) |
| Frequent VMS | 1.97 (1.78) | 0.02 (0.02) | 0.07 (0.05) | −0.03 (0.06) | 0.07 (0.06) | −0.004 (0.002) |
| Trend p | 0.23 | 0.14 | 0.14 | 0.49 | 0.20 | 0.14 |
a
Model 1: Unadjusted Model
b
Model 2: Adjusted for age, site, race/ethnicity, education, menopausal status, physical activity, alcohol use and BMI
c
Model 3: Model 2 + log-E2 and menstrual cycle day of blood collection
d
p<0.05 compared to reference group
e
Log- Transformed