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List of identified HVEM mutations for binding selectivity to it three ligands. Statistical p-values of pairwise comparisons are marked as: BTLA:LIGHT (italic), CD160:LIGHT (regular), and BTLA:CD160 (Bold).
| Mutations | TNFSF | IgSF | p-value (Welch’s t-test) | |
|---|---|---|---|---|
| LIGHT | CD160 | BTLA | ||
| E52K | + | − | − | 9.62E-03, 3.56E-03 |
| L87W | − | + | − | 6.58E-02, 5.15E-02 |
| D100R:M103K | − | − | + | 1.44E-03, 1.00E-03 |
| H86I:M103K | − | + | + | 1.22E-03, 7.31E-05 |
| G89F | + | + | − | 1.17E-02, 3.21E-03 |
| S58Q | + | − | + | 3.17E-03, 3.63E-04 |
