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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Cancer Res. 2020 Aug 27;80(21):4854–4867. doi: 10.1158/0008-5472.CAN-20-0384

Figure-2. Critical mutated immunological pathways and genes in cancer.

Figure-2.

(A) Human immune pathways and number of genes in each pathway. In total, 2,273 immune-related genes in 18 pathways are analyzed. (B) The PMB score for each immune-related pathway in cancer. Each dot represents a pathway in a specific cancer type. The immune score is calculated as the product of the proportion of mutated genes in the pathway and the percentage of mutated samples. Pathways are ranked by the PMB score. (C) The mutations of genes in cytokine receptor pathway in LUSC. Genes were ranked by the mutation frequency.