Table 2.
CircRNAs encoded by DNA Viruses and their Functions.
| Virus | CircRNA | Sequencing method | Function | Ref |
|---|---|---|---|---|
| EBV | circRPMS1 | rRNA depletion RNA | miRNA sponge for human and | [86] |
| sequencing | EBV-encoded miRNAs | |||
| circBART_1 | RNase R-resistant | Unknown | [88] | |
| circBART_2 | RNA-seq | |||
| circBHLF1 | ||||
| circLMP2 | ||||
| circEBNA_W1_C1 | RNase R-resistant | Function as host miRNA sponge | [89, 92] | |
| circEBNA_W2_C2 | RNA-seq | regulating virus infection, cell cycle, | ||
| circEBNA_U | and oncogenesis | |||
| circRPMS1 multiple variants | ||||
| circLMP2 multiple variants | ||||
| circBHLF1 | ||||
| circBGLF1_BHLF1 | ||||
| circBDLF1_BHLF1 | ||||
| circBXLF1_BHLF1 | ||||
| circBILF2_BHLF1 | ||||
| circBHRF1 | ||||
| KSHV | circvIRF4 | RNase R-resistant | Incorporation into viral particles for | [88, 94] |
| circPAN/K7.3 multiple | RNA-seq | preformed delivery, suggesting a | ||
| variants | potential function in early infection | |||
| Kcirc3 (ORF4, ORF6) | RNase R-resistant | Located within ORFs of viral lytic | [87] | |
| Kcirc29 (K7, PAN) | RNA-seq | genes, upregulated upon induction | ||
| Kcirc38 (ORF21, ORF22) | of the lytic cycle, and alter cell | |||
| Kcirc54 (ORF34) | growth | |||
| Kcirc55 (ORF34, 35, 36) | ||||
| Kcirc57 (ORF34, 35, 36, 37) | ||||
| Kcirc97 (ORF60, 61, 62) | ||||
| HPV | circE7 | Circular RNA | circE7 can be translated through | [30] |
| detection from NCBI | cap-independent mechanisms, | |||
| and TCGA RNA-Seq | which is essential for the | |||
| data | transformed growth of CaSki | |||
| cervical carcinoma cells | ||||