Fig. 6.

Mitochondrial metabolic scores, a measure of overall mitochondrial substrate utilization, demonstrated significant differences based on BMI, total FSH dose, and the number of mature oocytes retrieved. Mitochondrial substrate utilization was based on the estimated multiple linear regression model using observed data. A) Mitochondrial metabolic scores were found to be significantly higher in GCs of patients with higher numbers of mature oocytes retrieved (P < 0.05), after adjusting for the other factors in the model. In a backward selected best fit model using only the BMI and total FSH dosage administered, B) mitochondrial metabolic scores were found to be significantly higher in pooled GCs of patients with a higher BMI (P < 0.05). BMI was divided into 2 groups with the higher group being patients with a BMI of ≥ to 26 kg/m² (n = 20) and the lower group being patients with a BMI of <26 kg/m² (n = 20). C) Mitochondrial metabolic scores were found to be significantly lower as the patient’s FSH dose administered increased (P < 0.01). Following the Box-Cox transformation of the data and observing the Q-Q plots, the most outlying observations have been removed to ensure the normality of the response variables. For BMI, data are presented as the median (line inside box), first and third quartile (bottom and top of the box), and highest and lowest data points (top and bottom of whiskers) for mature oocytes retrieved and FSH dose administered, data are presented as a scatter plot of the individual patient values were lambda transformed for normalization showing the trend line and the 95% confidence interval