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. 2020 Oct 22;8:586581. doi: 10.3389/fcell.2020.586581

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Copyright © 2020 Gu, Wang, Wang, Luo, Wang, Ma, Hua, Liu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Promoter hypermethylation and low expression of LATS2 in IDH-mutant LGG. (A) LATS2 methylation level is increased in IDH-mutant LGG. (B) LATS2 mRNA level is decreased in IDH-mutant LGG. (C) Correlation between LATS2 methylation level and LATS2 mRNA level. RR indicates R squared value of linear regression. (D) Methylation level of different CpG islands in LATS2 promoter and gene body area. (E) Methylation-specific PCR of LGG samples. M: methylation-specific primer; U: unmethylation-specific primers; universal: universally methylated genomic DNA control; untreated: untreated U87 cell genomic DNA; product: ∼130 bp PCR products; primer: primer dimers. Quantitative result on the right. M/U ratio was calculated by comparing the bands from methylation-specific and unmethylation-specific primers of each sample. Mean and standard error were presented (*p < 0.05, *****p < 0.000005, t test).