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. 2020 Oct 22;8:586581. doi: 10.3389/fcell.2020.586581

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Copyright © 2020 Gu, Wang, Wang, Luo, Wang, Ma, Hua, Liu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hippo pathway target genes are not activated by LATS2 deficiency in IDH-mutant LGG. (A) YAP is activated in HEK293A cells with LATS2 knockdown. (B) cluster analysis of Hippo target gene expression in IDH-wildtype and mutant LGG. The Normalized RESM value was scaled across each gene to yield standard score (Z-score) (C) mRNA levels of Hippo target genes CTGF and CYR61 were decreased in IDH-mutant LGG. Correlation between CTGF/CYR61 mRNA level and LATS2 methylation level is shown. Mean and standard error were presented (*p < 0.05, ****p < 0.00005, t test).