Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 22;8:586581. doi: 10.3389/fcell.2020.586581

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Gu, Wang, Wang, Luo, Wang, Ma, Hua, Liu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Hippo pathway target genes are universally hypermethylated in IDH-mutant LGG. (A) cluster analysis of Hippo target gene methylation levels in IDH-wildtype and mutant LGG. The Normalized beta value is scaled across each gene to yield standard score (Z-score) (B) Methylation levels of Hippo target genes CTGF and CYR61 are significantly increased in IDH-mutant LGG. Correlation between CTGF/CYR61 methylation level and LATS2 methylation level is shown. Compared by t test (*****p < 0.000005, t test).