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. 2020 Oct 22;8:586581. doi: 10.3389/fcell.2020.586581

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Copyright © 2020 Gu, Wang, Wang, Luo, Wang, Ma, Hua, Liu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Low expression of YAP in LGG. (A) YAP methylation is elevated in IDH-mutant LGG. (B) YAP mRNA level is reduced in IDH-mutant LGG. (C) Correlation between YAP mRNA level and LATS2 methylation level. (D) IHC result of IDH-wildtype or mutant LGG samples and GBM samples. Left: Representative image; Right: Quantitative result. (E) YAP and TAZ mRNA levels in LGG and GBM. (F) YAP and TAZ methylation levels in LGG and GBM. (G) BTRC mRNA level in LGG and GBM. Mean and standard error were presented (****p < 0.00005, *****p < 0.000005, t test).