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. 2020 Oct 22;8:586581. doi: 10.3389/fcell.2020.586581

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Copyright © 2020 Gu, Wang, Wang, Luo, Wang, Ma, Hua, Liu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated expression of multiple Hippo pathway genes in IDH-mutant LGG. (A) TEAD2-4 are significantly downregulated in IDH-mutant LGG while TEAD1 shows a mild upregulation. (B) Correlation between ZYX mRNA level and LATS2 methylation level (left). ZYX is significantly downregulated in IDH-mutant LGG (right). (C) Correlation between AMOTL2 mRNA level and LATS2 methylation level (left). AMOTL2 is significantly upregulated in IDH-mutant LGG (right). (D) A proposed model of ineffective LATS2 hypermethylation. Mean and standard error were presented (*p < 0.05, ** < 0.005, *****p < 0.000005, t test).