Table 3.

Predictors of 28-day mortality and ICU mortality in the sepsis cohort—univariable logistic regression models.

Outcome variable	28-day mortality			ICU mortality
Variable	Odds ratio	95% confidence interval	p	Odds ratio	95% confidence interval	p
Demographics and pre-medication
Age (per 5 years increase)	1.23	1.02–1.50	0.033	1.06	0.89–1.27	0.511
Body mass index (per 5 kg/m2 increase)	0.72	0.41–1.25	0.245	0.57	0.30–1.08	0.085
Female sex	2.71	0.87–8.42	0.085	1.65	0.53–5.17	0.390
Anti-diabetic therapy	0.75	0.20–2.75	0.665	0.87	0.22–3.37	0.836
Statin therapy	0.45	0.13–1.57	0.210	0.56	0.15–2.08	0.384
Quantitative lipid parameters
HDL cholesterol (per 10 mg/l increase)	0.88	0.66–1.18	0.381	0.84	0.61–1.17	0.312
Triglycerides (per 10 mg/l increase)	0.98	0.93–1.04	0.501	0.99	0.93–1.05	0.715
Cholesterol (per 10 mg/l increase)	0.90	0.79–1.02	0.088	0.89	0.78–1.02	0.099
ApoA1 (per 10 mg/l increase)	0.92	0.80–1.07	0.294	0.87	0.73–1.03	0.099
Qualitative lipid parameters
Arylesterase activity (AEA) (per 10 mM/min/ml serum increase)	0.76	0.61–0.94	0.010	0.71	0.56–0.90	0.004
Cholesterol efflux capacity (per 10% increase)	0.20	0.03–1.45	0.111	0.11	0.01–1.03	0.053
Laboratory covariables
White blood count (per 1 g/L increase)	1.02	0.98–1.07	0.357	1.00	0.96–1.05	0.960
Hemoglobin (per 1 g/dl increase)	0.94	0.77–1.15	0.574	1.03	0.84–1.25	0.801
Platelets (per 100 g/L increase)	1.11	0.71–1.75	0.640	1.14	0.71–1.81	0.593
C-reactive protein (per 100 mg/l increase)	1.72	1.07–2.77	0.025	1.40	0.90–2.18	0.136
Serum bilirubin (per 1 mg/l increase)	0.89	0.74–1.08	0.245	0.94	0.80–1.11	0.484
Serum creatinine (per 1 mg/l increase)	1.01	0.85–1.19	0.905	1.04	0.88–1.23	0.653
Serum albumin (per 1 g/dl increase)	0.36	0.14–0.93	0.034	0.54	0.22–1.31	0.171
Sepsis severity and outcomes
SOFA score (per 1 point increase)	1.13	0.97–1.31	0.113	1.36	1.12–1.65	0.002

AEA, arylesterase activity; ApoA1, apolipoprotein A-I; HDL, high-density lipoprotein; SOFA, sequential organ failure assessment.