Figure 4.
Relative mRNA expression of genes encoding COL1A1, LOX, ELN, MMP 1, MMP 12, and TIMP 1 in gingival tissue of beagle dogs after sulforaphane treatment. COL1A1 (A), LOX (B), ELN (C), MMP 1 (D), MMP 12 (E), and TIMP 1 (F) mRNA levels in gingival tissue were quantified by real-time polymerase chain reaction. The symbol (*) indicates statistical significance between the control group and experimental group (*p < 0.05, Wilcoxon signed rank test).
DMSO, Dimethylsulfoxide; COL1A1, collagen type I alpha 1; LOX, lysyl oxidase; ELN, elastin; MMP, matrix metalloproteinase; TIMP, tissue inhibitor of metalloproteinase.