Figure 2.

Lipid fingerprinting of the Piezo1 channel. (A) Given are the average and sem (standard error of the mean) of the depletion and enrichment (D/E) index of all lipid groups in three simulations within a 20-Å cutoff of Piezo1. Lipids are separated by the leaflet and by their tendency to flip-flop (these are noted as “both”). The D/E index is also calculated for lipids grouped according to tail saturation. The D/E of different PIP species are shown in the inset. (B) Given are the densities of PIPs, cholesterol, PIs, and PSs or PAs around Piezo1, shown as a fraction of the bulk density. The dashed lines represent the halfway point between the center of the system (Piezo1’s pore) with the bilayer bulk. To see this figure in color, go online.