Figure 3.

Significant contacts made with the lipids either in the upper leaflet (top), lower leaflet (bottom), or that can flip-flop between leaflets (inset). Residues that interact with a given lipid type are colored on the surface of a monomer of Piezo1, as viewed from two sides. Darker colors represent lipids interacting with, or occupying, that region of the protein for a larger percentage of the 20–30-μs analysis window of the simulations. An example colormap is shown to the left of the result for the PC. To see this figure in color, go online.