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The strategies for modifying UCB-derived NK cells include enhancing activation (such as: increase the expression of activating receptor: NKG2D and decrease the expression of inhibitory receptor: NKG2A), targeting tumor antigen and overcoming the immunosuppressive tumor microenvironment (such as IL-6, IL-10, and TGFβ). PEBLs, anti-NKG2A protein expression blockers; CAR, chimeric antigen receptor; UCB, umbilical cord blood; NK cells, natural killer cells.
