Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

editorial

. 2020 Oct 22;7:602271. doi: 10.3389/fcvm.2020.602271

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Bartoli-Leonard and Aikawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Development of valve disease. Development of valve disease occurs following prolonged inflammation driven by macrophage and leukocyte infiltration and via VIC differentiation through accumulation of apoptotic bodies and calcific matrix vesicles. Ultimately resulting in collagen remodeling, leaflet thickening, and valvular calcification. qVIC, quiescent valve interstitial cell; aVIC, activated valve interstitial cell; oVIC, osteogenic valve interstitial cell; EMT, endothelial-to-mesenchymal transition; LDL, low-density lipoprotein; RUNX2, Runt related transcription factor; PCSK9i, proprotein convertase subtilisin/kexin type 9 inhibitor; AI, Artificial Intelligence.