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. 2020 Nov 3;10:18945. doi: 10.1038/s41598-020-75863-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Safety (bleeding risk) of DOAC. (a) Major bleeding (MB), (b) clinically relevant non major bleeding (CRNMB), (c) all bleeding (composite MB and CRNMB). Forest plots show risk ratio (RR) of VTE recurrence of pooled data from all studies and subgroup analyses of studies evaluating DOAC compared to LMWH and DOAC compared to VKA. Boxes superimposing RR estimates are proportional to the weight of the included study. Heterogeneity between RCT is assessed by the I² statistic.