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. 2020 Sep 11;119(8):1580–1589. doi: 10.1016/j.bpj.2020.09.002

Figure 3.

Figure 3

The addition of d(TGA) triplets decreases the Tm of (YGA)6 oligomers. Shown is normalized temperature versus absorbance curves for (YGA)6 oligomers with d(TGA) triplets (n = 6, 3, 1, and 0). (A) At pH 5.5, all variants except (TGA)6 exhibit two-state melting. (B) At pH 7.0, (CGA)6 is the only variant to retain two-state melting. (CGA)5TGA and TGA(CGA)5 have broad melting curves with multiple transitions, whereas (TGA)6 and (CGATGA)3 do not have clear melting transitions, suggesting a lack of stable structure formation. To see this figure in color, go online.