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. 2020 Nov 3;10:18921. doi: 10.1038/s41598-020-75751-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed miRNAs found (a) 2 h after an oral administration of a cholesterol-enriched (40 mg) olive oil (250 µL) solution (acute), (b) 4 days after the consumption of a high-fat diet (HFD), and (c) 20 weeks after HFD, in the small intestine (whole) of male C57BL/6 mice (n ≥ 4 per group). Up- and down-regulated miRNAs are shown as red and blue dots, respectively. (d) Venn diagram represents the number of common differently expressed miRNAs in acute, 4 days and 20 weeks studies. mmu-miR-218-2-3p was common among the three studies; mmu-miR-147-3p, -138-1-3p, -1894-3p and -666-3p were common between the two chronic consumption studies; mmu-miR-449c-5p, -1894‐5p and ‐217‐5p were shared by the 20 weeks and acute experiments; mmu‐miR‐879‐3p, ‐711, ‐146b‐3p, ‐216b‐5p, ‐212‐3p, ‐216a‐5p and ‐291a-5p were common to the 4 days and acute studies. (e) List of 35 miRNAs selected for further validation.