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. 2020 Nov 3;10:18921. doi: 10.1038/s41598-020-75751-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Males (squares) and females (circles) weight (g) for WT (Dicer1^loxP/loxP, Vil-cre(−)) and KO (Dicer1^loxP/loxP, Vil-cre(+)) mice; n ≥ 15 per group. Corresponding means and SD bars are shown for each group. Two-way ANOVA was followed by Bonferroni’s post-hoc tests for multiple comparisons. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (b) Plasma triglycerides and cholesterol levels 2 h after an oral administration of a cholesterol-enriched olive oil solution (grey), compared to controls (water; white); n ≥ 10 per group. Data are represented as mean ± SD. Two-way ANOVA was followed by Bonferroni’s post-hoc tests for multiple comparisons. p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. (c) Plasma cholesterol (red) and triglycerides (blue) FPLC profile in WT and Dicer1 KO mice submitted to an oral lipid challenge or water (controls), n = 4 per group.