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. 2020 Nov 3;3:642. doi: 10.1038/s42003-020-01364-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a A trajectory of hepatic development was determined during E9.5–E15.5 by Monocle analysis. No branches on the trajectory were found, and the predicted pseudotime of the trajectory agreed with the gestation day. b The expressions of Alb, Nanog, Mki67 were shown in the hepatic trajectory. c The metabolic function of hepatoblasts/hepatocytes increased while the cell pluripotency and the proliferation rate decreased during liver development based on “hepatic score”, “stemness score”, and “proliferation score” from E9.5 to E15.5. d Dynamic regulation of gene expression during hepatoblast maturation and the respective functions of up/downregulated genes were identified. e The composition of upregulated or downregulated genes during E9.5–E15.5 were shown. f Genes for the metabolic function of the liver (such as Alb and Apoh) from E9.5 to E15.5 were upregulated, while the downregulated genes were enriched in cell cycles, RNA splicing, cell division, and translation (such as Mdk and Set). g The network of genes that were downregulated during the hepatoblasts maturation. Genes labeled by green were downregulated, while genes labeled by white were not detected.