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. 2020 Nov 4;10:18994. doi: 10.1038/s41598-020-76130-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of Treg cells and myeloid-derived suppressor cells (MDSCs). (A) polymorphonuclear (PMN)-MDSC frequencies in association with high or low levels of Treg cells and coefficient correlation of Treg cells and PMN-MDSC frequencies in the discovery cohort. (B) Overall survival (OS) when levels of Treg cells are high and PMN-MDSCs are low and when levels of Treg cells are high and monocytic (M)-MDSCs are low compared with low levels of Treg cells and high levels of MDSCs in the discovery cohort. (C) PMN-MDSC frequencies in association with high or low levels of Treg cells and the coefficient correlation of Treg cells and PMN-MDSC frequencies in the validation cohort. (D) OS with high levels of Treg cells and low levels of PMN-MDSCs or M-MDSCs compared with low levels of Treg cells and high levels of MDSCs in the validation cohort. The median cutoff values of Treg cells are 1.6% (range 0.37–3.73) in discovery and 0.75% (range 0.11–2.67) in the validation cohort. The median cutoff values for PMN-MDSCs are 3.9% (range 0.22–70.55) in the discovery cohort and 4.4% (range 0.3–62) in the validation cohort. The median cutoff values for M-MDSCs are 11.1% (range 3–29.34) in the discovery cohort and 6.7% (range 1.5–30.8) in the validation cohort. High Treg cells and low PMN-MDSCs: discovery n = 19, validation n = 12. Low Treg cells and high PMN-MDSCs: discovery n = 18, validation n = 12. High Treg cells and low M-MDSCs: discovery n = 16, validation n = 9. Low Treg cells and high M-MDSCs: discovery n = 14, validation n = 10. The center value is the mean ± SEM. Kaplan–Meier survival curves were plotted with a median cutoff. Statistical significance was determined by log-rank (Mantel-Cox) regression analysis, with the level of significance at P $\leq$ 0.05.