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. 2020 Nov 4;10:19018. doi: 10.1038/s41598-020-76038-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Bone loss and expression profile of Th17 and Treg markers in periodontal lesions. (A) The palatal vision of the upper right jaws by SEM. (B) The buccal and palatal vision of the right upper jaws with linear measurements between the cement-enamel junction (CEJ) and alveolar bone crest (ABC) by µCT. (C) The linear distance between CEJ and the ABC measured at days 10, 15, and 20 post-ligations and control animals (baseline). (D) Heat-map visualization of the log2 fold-change mean value (n = 4). (E) mRNA fold-change levels of cytokines, transcription factors, and membrane receptors associated with Th17 and Treg profiles in periodontal lesions of animals with ligature-induced periodontitis and control animals (BL). *P < 0.05, ***P < 0.001.