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. 2020 Nov 4;10:19034. doi: 10.1038/s41598-020-75834-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Hyperoxia-induced alveolar simplification in Keap1^f/wt pups. Keap1^f/wt pups at PND1 were exposed to room air (RA) or hyperoxia (Hyp) for 72 h, allowed to recover at room air, and sacrificed at PND18. The left lung was fixed, sectioned, and stained with H&E. (a) A representative image of lung sections of the Keap1^f/wt neonatal mice exposed to RA or Hyp (20x). Images captured with Aperio Image Scope are presented. Scale bar: 100 μm. (b) The average MCL analyzed by morphometry (n = 3). Note that the MCL of the wildtype mice used for comparison are derived from Fig. 2B. (c) Nrf2 target gene expression in the lungs of room-air exposed 1-day-old (PND1) Keap1^f/wt pups (n = 4). The dotted line represent values of respective genes noted in WT pups as shown in Fig. 2. *, **, compared to WT mice.