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. 2020 Nov 4;10:19065. doi: 10.1038/s41598-020-76107-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Matrix PGs have different effects on the contraction of engineered collagen microtissues. (A,B) Representative light microscopy images of PDMS cantilever displacement in µTUGs. (C) SHG imaging of µTUGs made using collagen and NIH 3T3 fibroblasts. (D) Quantification of increased displacement observed with inclusion of 0.1 mg/ml versican (Ver) in 1.5 mg/ml collagen (Col) microtissue. (E) Quantification of the displacement observed in collagen microtissues with or without aggrecan (Agg; 0.1 mg/ml), decorin (Dec; 0.1 mg/ml), or lumican (Lum; 0.01 mg/ml or 0.05 mg/ml). N > 30 microtissues per each platform, three independent experiments (platforms) per condition. Points represent mean per platform. Scale bar = 200 µm. Data represent mean ± SE. *P < 0.05 and **P < 0.01.