Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 22;8:595593. doi: 10.3389/fcell.2020.595593

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Wang, Chiba, Jia, Yoshizaki, Saito, Yamada, Qin and Fukumoto.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Expression patterns of claudin family members during tooth development. (A) Heatmap of Cap Analysis Gene Expression (CAGE)-based claudin genes expression in embryonic (E) day E11 mouse whole body and tooth germs at various developmental stages. (B) Differential expression analysis of cell-type marker genes using Uniform Manifold Approximation and Projection (UMAP) visualization of single-cell datasets from postnatal (P) day P7 Krt14-RFP mouse incisors. Krt14, epithelium marker; Ambn, ameloblast marker; Shh, IEE and pre-ameloblast marker; Notch1 and Alpl, SI markers; Notch2, SR and OEE marker; Smpd3, odontoblast marker; Igfbp4, dental follicle and Postn, periodontal ligament markers; Fn1, mesenchyme marker; Hba-a2, erythrocyte marker; C1qc, leukocyte marker; Mpz, neural cell marker; Cdh5, endothelial cell marker. IEE, inner enamel epithelium; Pre-Am, pre-ameloblast; Am, ameloblast; SI/SR/OEE, stratum intermedium, stellate reticulum, and outer enamel epithelium; DF, dental follicle; Od, odontoblast; PDL, periodontal ligament; Ery, erythrocyte; Leuko, leukocyte; Endo, endothelium; Neu, neural cell. Red dashed lines indicate the cell cluster that highly expressed marker genes. (C) Differential gene expression analysis of claudin family members detected in single-cell datasets from P7 Krt14-RFP incisors. Red dashed lines indicate the cell cluster that highly expressed marker genes.