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. 2020 Oct 22;11:592010. doi: 10.3389/fimmu.2020.592010

Figure 2.

Figure 2

Mechanism of HLA-G interacting with decidual NK cells to promote fetal growth. HLA-G on EVTs binds to ILT2 on NK cells, activates the PI3K-AKT signal pathway and induces expression of transcription factor PBX1. PBX1 upregulates the secretion of growth-promoting factor PTN and OGN, facilitating early fetal growth.