Table 1.
Details of the spectrum of publications related to Midkine (MK), highlighting the vast number of works across areas such as cancer, but the striking lack of research in the area of perinatal brain injury (PubMed search, August 20, 2020).
| Search term | Number of PubMed hits | Hits relevant to the intended search for MK in perinatal brain injury |
|---|---|---|
| Midkine | 956 (98 reviews) | – |
| Midkine AND Cancer | 431 (41 reviews) | – |
| Midkine AND Brain | 158 (14 reviews) | – |
| Midkine AND Neuroprotection | 18 (5 reviews) | – |
| Midkine AND Nanoparticle | 8 | – |
| Midkine AND Inflammation | 92 (12 reviews) | – |
| Midkine AND Infant AND Brain | 3 | 1 (22) |
| Midkine AND Neonatal AND Brain | 7 | 0 |
| Midkine AND Perinatal AND Brain | 7 | 0 |
| Midkine AND Premature or Preterm birth | 6 | 1 (23) |
| Midkine AND Hypoxic-ischemic Encephalopathy | 0 | 0 |
| Midkine AND Fetal Growth restriction OR intrauterine growth restriction | 0 | 0 |