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. 2020 Oct 22;11:577564. doi: 10.3389/fmicb.2020.577564

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Copyright © 2020 Liu, Yang, Zhang, Jia and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nucleotides supplementation activates bacterial metabolism (Yang et al., 2019). (A) Purine and pyrimidine biosynthesis pathways and feedback inhibition by products. (B) The addition of exogenous pyrimidine (cytosine, thymine, and uracil) displays a feedback inhibition on the pyrimidine biosynthesis and triggers purine biosynthesis, thus increasing ATP demand, which drives increased activity through central carbon metabolism and cellular respiration, ultimately restoring the killing of antibiotics against tolerant bacteria.