Table 1.
Baseline characteristics.
| ∧ | Total N = 301 | Apical HCM N = 80 | Septal HCM N = 221 | P-value |
|---|---|---|---|---|
| Male, n (%) | 197 (65) | 57 (71) | 140 (63) | 0.22 |
| Age at diagnosis, years | 55 ± 17 | 57 ± 17 | 54 ± 17 | 0.39 |
| BMI, kg/m2 | 28 ± 5 | 27 ± 4 | 29 ± 5 | 0.02 |
| Familial HCM, n (%) | 59 (20) | 17 (21) | 42 (19) | 0.74 |
| Family history of SCD, n (%) | 62 (21) | 20 (25) | 42 (19) | 0.26 |
| Hypertension, n (%) | 168 (56) | 45 (56) | 23 (56) | 1.00 |
| Dyslipidemia n (%) | 152 (51) | 42 (53) | 110 (50) | 0.70 |
| Coronary artery disease, n (%) | 54 (18) | 12 (15) | 42 (19) | 0.50 |
| Diabetes, n (%) | 37 (12) | 7 (9) | 30 (14) | 0.32 |
| Active smoking, n (%) | 21 (7) | 8 (10) | 13 (6) | 0.21 |
| Atrial fibrillation, n (%) | 104 (35) | 30 (38) | 74 (33) | 0.58 |
| Atrial flutter, n (%) | 40 (13) | 13 (16) | 27 (12) | 0.44 |
| CKD (≤60 mL/min], n (%) | 28 (9) | 9 (11) | 19 (9) | 0.50 |
| Septal reduction therapy | ||||
| Any septal reduction, n (%) | 60 (20) | 0 | 60 (27) | <0.001 |
| Septal myectomy, n (%) | 45 (15) | 45 (20) | ||
| Septal ethanol ablation, n (%) | 15 (5) | 15 (7) | ||
| Cardiac implantable devices | ||||
| ICD, n (%) | 108 (36) | 34 (43) | 74 (33) | 0.17 |
| Primary prevention, n (%) | 80 (27) | 21 (27) | 59 (27) | 1.00 |
| Secondary prevention, n (%) | 28 (9) | 13 (16) | 15 (7) | 0.02 |
| Pacemaker, n (%) | 44 (15) | 9 (11) | 34 (15) | 0.46 |
Continuous variables are presented as mean ± SD or absolute numbers and percentages where appropriate.
BMI, body mass index; SCD, sudden cardiac death; CKD, chronic kidney disease; ICD, implantable cardioverter defibrillator.