FIGURE 4.

Pathway analysis of the dysregulated metabolites and lipids in the CSF of POD patients. Fifteen selected metabolites and lipids were involved in the D-Glutamine and D-glutamate metabolism (2 hit), Glycerophospholipid metabolism (4 hits), Alanine, aspartate and glutamate metabolism (3 hits), Sphingolipid metabolism (2 hits), Histidine metabolism (2 hits) and Arginine biosynthesis (2 hits). The color gradient indicates the significance of the pathway ranked by p-value (y-axis; yellow: higher p-values, red: lower p-values), and circle size indicates the pathway impact score (x-axis; the larger circle, the higher impact score). Significantly affected pathways with low p-values and high pathway impact scores are labeled.