TABLE 2.

Differentiating metabolites between POD and Non-POD groups identified from the metabolomic data.

Pathway	Metabolites	VIP	P-value	FC (P/N)	Trend
Amino sugar metabolism	N-Acetylmannosamine	2.67	1.52E-03	0.39	Down
Amino acid metabolism	L-Saccharopine	2.60	1.88E-03	0.57	Down
Fatty acid metabolism	9-Trans-Palmitelaidic acid	2.53	2.64E-03	2.58	Up
Fatty acid metabolism	Citramalate	2.51	2.82E-03	0.66	Down
Glycolysis	D-Glucose 6-phosphate	2.23	8.85E-03	2.94	Up
Amino acid metabolism	Creatine	2.21	9.51E-03	0.75	Down
Histidine metabolism	Histamine	2.21	1.00E-02	0.47	Down
Amino acid metabolism	Methionine	2.21	1.01E-02	0.57	Down
Fatty acid metabolism	Trans-Vaccenic acid	2.2	1.02E-02	0.88	Down
Amino sugar metabolism	N-Acetylgalactosamine	2.14	1.28E-02	0.26	Down
Amino acid metabolism	Glutamate	2.14	1.32E-02	4.21	Up
Purine metabolism	Hypoxanthine	2.11	1.41E-02	0.67	Down
Amino acid metabolism	N-Methylproline	1.98	2.28E-02	0.47	Down
Amino acid metabolism	Glutamine	1.96	2.33E-02	0.64	Down
Lipid metabolism	rac-Glycerol 3-phosphoate	1.91	2.70E-02	0.60	Down
Lipid metabolism	sn-Glycero-3-phosphocholine	1.86	3.25E-02	1.54	Up
Amino sugar metabolism	D-Glucosamine-6-phosphate	1.79	4.02E-02	0.63	Down
Amino acid metabolism	Dopamine	1.71	4.94E-02	13.15	Up

VIP, variable importance in the projection; FC, fold change.