TABLE 3.

The top 20 differentiating lipids between POD and Non-POD groups identified from the lipidomic data.

Pathway	Lipids	VIP	P-value	FC (P/N)	Trend
Sphingolipid metabolism	Cer-NS (d40:2); Cer-NS (d18:1/22:1)	2.96	4.41E-05	2.51	Up
Glycerophospholipid metabolism	PE (40:6); PE (18:0–22:6)	2.86	8.00E-04	0.59	Down
Glycerophospholipid metabolism	PE (38:7e); PE (16:1e/22:6)	2.76	1.35E-03	0.66	Down
Glycerophospholipid metabolism	PE (40:7e); PE (18:1e/22:6)	2.70	1.74E-03	0.43	Down
Glycerolipid metabolism	DAG (44:5e); DAG (22:3e/22:2)	2.61	4.52E-04	0.47	Down
Glycerolipid metabolism	LDGCC (34:1)	2.49	9.05E-04	0.6	Down
Sphingolipid metabolism	Cer-NS (d50:1); Cer-NS (d22:1/28:0)	2.39	1.61E-03	2.18	Up
Sphingolipid metabolism	Cer-NS (d52:1); Cer-NS (d22:1/30:0)	2.27	2.89E-03	3.00	Up
Sphingolipid metabolism	Cer-NS (d42:4); Cer-NS (d22:3/20:1)	2.26	3.03E-03	1.79	Up
Glycerophospholipid metabolism	PC (34:3)	2.18	4.47E-03	75.52	Up
Glycerophospholipid metabolism	PC (40:6); PC (18:0–22:6)	2.12	1.69E-02	0.51	Down
Glycerophospholipid metabolism	PC (33:1); PC (16:0–17:1)	2.06	2.04E-02	0.74	Down
Glycerophospholipid metabolism	PC (32:2)	2.02	8.79E-03	1.60	Up
Sphingolipid metabolism	Sphinganine (25:0)	2.02	9.11E-03	0.42	Down
Sphingolipid metabolism	SM (d34:1); SM (d18:1/16:0)	1.96	1.17E-02	4.78	Up
Sphingolipid metabolism	SM (d44:2); SM (d21:2/23:0)	1.92	1.34E-02	1.59	Up
Sphingolipid metabolism	SM (d34:2); SM (d14:2/20:0)	1.84	1.84E-02	1.26	Up
Glycerophospholipid metabolism	PC (37:3)	1.82	1.99E-02	15.33	Up
Glycerophospholipid metabolism	PC (33:2)	1.80	2.14E-02	1.65	Up
Sphingolipid metabolism	SM (d42:2); SM (d18:1/24:1)	1.79	2.18E-02	1.27	Up

VIP, variable importance in the projection; FC, fold change; Cer-NS, ceramide non-hydroxyfatty acid-sphingosine; PE, phosphatidylethanolamine; DAG, diacylglycerol; LDGCC, lysodiacylglyceryl-3-O-carboxyhydroxymethylcholine; PC, phosphatidylcholine; SM, sphingomyelin.