Table 2.
Original: Overview of the effect of OT on the male reproductive tract (+ = increasing; − = decreasing; Ø = no effect).
| Effect on smooth muscle contractility | Effect on cell proliferation | Other effects | |||
|---|---|---|---|---|---|
| Testis |
+ mouse (102) + rat at spermatogenesis stage VII-VIII (100) Ø rat at spermatogenesis stage IV-V (100) Ø rat, rabbit (81) |
Spermatogenesis: + rabbit spermatogonia (103) Ø mouse (104) + mouse (62) |
After OT-addition: Less degeneration of spermatocytes during meiosis in rats (103) + spermatozoa output in sheep (70, 105) + OTR-expression (62) |
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| Epididymis |
+ rat caput (106, 107) Ø rat caput (108) + cow caput (77) − cow corpus (77) + rabbit cauda (109) + sheep cauda (110) Ø rat cauda (108) + mouse cauda (111, 112) − cow proximal cauda (77) + cow mid- and distal cauda (77) Ø rat, rabbit (not specified which part) (81) |
Tissue that had been blocked by an α-adrenergic-antagonist: + ram cauda (while norepinephrine could not) (110) |
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| Vas deferens |
+ sheep (110) Ø rat, rabbit (81) Ø cow (77) − rat (113) |
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| Prostate |
+ human (BPH tissue) (114), + rat, dog, guinea pig (114, 115) Ø rat, rabbit (81) |
Without gonadal steroids | With gonadal steroids | 5α-reductase-activity: + PrEC but not in PrSC (116) |
|
| Human prostatic stromal cells (PrSC) |
− (2) + (36) |
− (2) | Prostate size after OT injection: + in castrated rats (117, 118) + in mice (36) |
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| Human prostatic epithelial cells (PrEC) PrSC (co-cultured with PrSC) |
Ø (2) + (36) Ø (2) |
Ø (2) − (2) |
OTR-expression: + in BPH-tissue (36, 38, 59, 119) + with age (37, 38) + in cancer tissue (120) − after OT-addition in PC-3 cells (39) Ø after OT addition in PrEC (39) |
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| Androgen independent malignant cells (PC-3) |
+ (39) Ø (2, 120) |
+ (2) Ø (39) |
OT concentration: + in BPH-tissue (36, 54, 121) + in cancer tissue (120) + in serum of BPH-patients (36) |
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| Seminal vesicles |
Ø rat (122) + rat, dog, guinea pig (115) Ø rat, rabbit (81) |
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