TABLE 3.
Differential expression of pathways in PBMC from PM females.
| Upregulated | Raw p |
| HIF-1 signaling pathway | 0.0011698 |
| Glycolysis or Gluconeogenesis | 0.013441 |
| Fructose and mannose metabolism | 0.02419 |
| Neomycin, kanamycin and gentamicin biosynthesis | 0.036192 |
| Central carbon metabolism in cancer | 0.091013 |
| Bacterial invasion of epithelial cells | 0.10011 |
| Alzheimer disease | 0.13034 |
| Transcriptional misregulation in cancer | 0.15592 |
| Pentose phosphate pathway | 0.19871 |
| Downregulated | Raw p |
| Ribosome | 1.24E-17 |
| Spliceosome | 0.016999 |
| Propanoate metabolism | 0.025582 |
| Pyruvate metabolism | 0.033013 |
| Proteasome | 0.042895 |
| Valine, leucine and isoleucine degradation | 0.0482 |
| Thermogenesis | 0.089012 |
| Non-homologous end-joining | 0.091438 |
| Complement and coagulation cascades | 0.1142 |
| RNA transport | 0.12057 |
| Fatty acid elongation | 0.18073 |
| Butanoate metabolism | 0.18677 |
| Citrate cycle (TCA cycle) | 0.19871 |
For the detailed list of proteins identified by proteomics analysis see Supplementary Dataset. Proteomics analysis was evaluated in 2 controls and 3 PM without FXTAS (Table 1).