Table 1.
Five-year overall survival and hazard ratios of total mortality associated with selected demographic and clinical characteristics among patients with colon cancer: results from the National Cancer Database
| Variables | No. of deaths | 5-y overall survival (%) | HR (95% CI)d |
|---|---|---|---|
| Age groups | |||
| <50 | 15,982 | 61.9 | 1.00 |
| 50-64 | 46,670 | 62.0 | 1.09 (1.07-1.11) |
| 65-74 | 49,672 | 57.3 | 1.25 (1.23-1.28) |
| ≥75 | 109,403 | 39.1 | 2.15 (2.10-2.20) |
| Sex | |||
| Male | 108,836 | 50.9 | 1.00 |
| Female | 112,891 | 52.8 | 0.88 (0.88-0.89) |
| Racea | |||
| White | 186,216 | 52.0 | 1.00 |
| Black | 28,180 | 48.8 | 1.10 (1.09-1.12) |
| Other | 5,651 | 60.5 | 0.84 (0.82-0.86) |
| Year of diagnosis | |||
| 2004-2006 | 75,113 | 50.7 | 1.00 |
| 2007-2009 | 74,575 | 51.5 | 0.99 (0.98-1.00) |
| 2010-2012 | 72,039 | 53.4 | 0.93 (0.92-0.94) |
| Residencea | |||
| Metro | 175,770 | 52.6 | 1.00 |
| Urban | 32,070 | 50.4 | 0.98 (0.96-0.99) |
| Rural | 4,698 | 50.6 | 0.97 (0.94-1.00) |
| Annual household incomea | |||
| <$30,000 | 32,745 | 48.2 | 1.00 |
| $30,000-$34,999 | 41,695 | 50.0 | 0.96 (0.95-0.98) |
| $35,000-$45,999 | 60,492 | 51.8 | 0.93 (0.92-0.95) |
| ≥$46,000 | 78,450 | 54.9 | 0.90 (0.88-0.92) |
| Insurancea | |||
| No insurance | 6,862 | 50.9 | 1.00 |
| Private insurance | 54,041 | 63.6 | 0.75 (0.73-0.77) |
| Government insurance | 157,245 | 45.9 | 0.95 (0.93-0.98) |
| Educational attainmenta,b | |||
| ≥29% | 37,687 | 49.8 | 1.00 |
| 20%-28.9% | 52,274 | 50.6 | 1.02 (1.00-1.03) |
| 14%-19.9% | 54,004 | 51.6 | 1.01 (0.99-1.02) |
| <14% | 69,424 | 54.8 | 0.97 (0.95-0.98) |
| Facility typea | |||
| Community | 29,849 | 49.9 | 1.00 |
| Comprehensive community | 107,454 | 51.6 | 0.96 (0.94-0.97) |
| Academic/research program | 56,140 | 52.7 | 0.87 (0.85-0.88) |
| Integrated network | 24,351 | 51.3 | 0.95 (0.93-0.96) |
| Charlson comorbidity score | |||
| 0 | 141,997 | 55.3 | 1.00 |
| 1 | 53,699 | 47.9 | 1.21 (1.20-1.22) |
| 2 | 26,031 | 34.4 | 1.70 (1.68-1.73) |
| Tumor stage | |||
| I | 27,981 | 74.1 | 1.00 |
| II | 44,025 | 62.0 | 1.21 (1.19-1.23) |
| III | 58,436 | 55.1 | 1.75 (1.73-1.78) |
| IV | 91,285 | 11.8 | 7.71 (7.60-7.82) |
| Tumor histology | |||
| Adenocarcinomas | 210,914 | 52.5 | 1.00 |
| Others | 10,813 | 33.2 | 1.21 (1.19-1.24) |
| Tumor gradea | |||
| Well differentiated | 16,078 | 64.6 | 1.00 |
| Moderately differentiated | 119,726 | 56.7 | 1.15 (1.13-1.17) |
| Poorly differentiated | 50,797 | 40.5 | 1.49 (1.46-1.52) |
| Undifferentiated | 6,023 | 39.4 | 1.54 (1.49-1.59) |
| Treatment adherence statusc | |||
| Adherence | 124,095 | 60.0 | 1.00 |
| Non-adherence | 97,632 | 34.5 | 1.93 (1.92-1.95) |
Abbreviations: OS, overall survival; HR, Hazard Ratio.
a
Unknown data was not shown.
b
Educational attainment refers to the percentage of adults who did not graduate from high school in the patient’s area of residence.
c
Adherence status to NCCN treatment guidelines.
d
HRs were derived from models including all variables listed in the table.