Table 3.
Factors associated with non-adherence to NCCN treatment guidelines for colon cancer patients older than 75 years: results from the National Cancer Database
| Variables | Adherent (n, %) | Non-adherent (n, %) | OR (95% CI)a |
|---|---|---|---|
| Sex | |||
| Male | 44,872 (43.6) | 33,799 (39.7) | 1.00 |
| Female | 58,019 (56.4) | 51,422 (60.3) | 1.12 (1.09-1.14) |
| Raceb | |||
| White | 92,594 (90.0) | 75,526 (88.6) | 1.00 |
| Black | 7,344 (7.1) | 7,117 (8.4) | 1.16 (1.11-1.21) |
| Other | 2,281 (2.2) | 1,933 (2.3) | 1.01 (0.94-1.08) |
| Residenceb | |||
| Metro | 83,634 (81.3) | 69,224 (81.2) | 1.00 |
| Urban | 13,573 (13.2) | 10,994 (12.9) | 0.93 (0.90-0.96) |
| Rural | 2,084 (2.0) | 1,731 (2.0) | 0.90 (0.84-0.97) |
| Annual household incomeb | |||
| <$30,000 | 12,109 (11.8) | 10,853 (12.7) | 1.00 |
| $30,000-$34,999 | 18,167 (17.7) | 15,297 (18.0) | 0.98 (0.94-1.02) |
| $35,000-$45,999 | 28,772 (28.0) | 23,790 (27.9) | 0.96 (0.92-1.00) |
| ≥$46,000 | 40,803 (39.7) | 32,556 (38.2) | 0.96 (0.92-1.00) |
| Insuranceb | |||
| No insurance | 310 (0.3) | 369 (0.4) | 1.00 |
| Private insurance | 9,428 (9.2) | 7,462 (8.8) | 0.72 (0.61-0.86) |
| Government insurance | 92,028 (89.4) | 76,199 (89.4) | 0.75 (0.64-0.89) |
| Educational attainmentb,c | |||
| ≥29% | 13,591 (13.2) | 12,306 (14.4) | 1.00 |
| 20%-28.9% | 22,190 (21.6) | 18,760 (22.0) | 0.95 (0.92-0.99) |
| 14%-19.9% | 26,439 (25.7) | 21,805 (25.6) | 0.92 (0.89-0.96) |
| <14% | 37,633 (36.6) | 29,627 (34.8) | 0.89 (0.85-0.93) |
| Facility type | |||
| Community | 14,064 (13.7) | 12,522 (14.7) | 1.00 |
| Comprehensive community | 53,067 (51.6) | 44,496 (52.2) | 0.91 (0.88-0.94) |
| Academic/research program | 24,301 (23.6) | 18,801 (22.1) | 0.79 (0.76-0.81) |
| Integrated network | 11,459 (11.1) | 9,402 (11.0) | 0.87 (0.84-0.91) |
| Year of diagnosis | |||
| 2004-2006 | 33,130 (32.2) | 30,767 (36.1) | 1.00 |
| 2007-2009 | 34,619 (33.6) | 27,092 (31.8) | 0.77 (0.75-0.79) |
| 2010-2012 | 35,142 (34.2) | 27,362 (32.1) | 0.72 (0.70-0.74) |
| Charlson comorbidity score | |||
| 0 | 65,321 (63.5) | 51,801 (60.8) | 1.00 |
| 1 | 26,586 (25.8) | 22,485 (26.4) | 1.11 (1.08-1.14) |
| 2 | 10,984 (10.7) | 10,935 (12.8) | 1.42 (1.38-1.47) |
Abbreviations: OR, Odds Ratio.
a
ORs were derived from the model including all variables listed in the table with adjustment of histology, TNM stage, grade.
b
The percentages were calculated based on all the population. OR of unknown data was not shown.
c
Educational attainment refers to the percentage of adults who did not graduate from high school in the patient’s area of residence.