Figure 4.

KLHL2 suppresses cell proliferation, migration and invasion partially dependent on ARHGEF7. A, B. Western blot (left panel) and cell proliferation assay (right panel) of 786-O and A498 cells transfected with control or indicated siRNAs. Standard deviation (S.D.) of at least three independent experiments is shown to indicate statistical significance. * represent P < 0.05. C-F. 786-O and A498 cells were transfected with control or indicate siRNAs. Migration and invasion assays were performed using Trans-well chambers without or with Matrigel as described before. Representative images of cell migration and invasion assays were shown on the upper panel, and the quantitative analysis is shown on the lower panel. The mean values (S.D.) of three independent experiments are shown (*, P < 0.05).