Table 4.

Multivariable analysis of all-cause mortality, locoregional recurrence, and distant metastasis for patients receiving neoadjuvant chemotherapy and total mastectomy stratified by pathologic response ratio of T, N, or AJCC stage

		All-cause mortality		LRR		DM
		HR (95% CI)	p	HR (95% CI)	p	HR (95% CI)	p
Response of T-stages ratio	Equal-stage	ref	< 0.0001	ref	< 0.0001	ref	< 0.0001
	T pCR	0.37 (0.24-0.55)		0.27 (0.13-0.57)		0.49 (0.35-0.70)
	Downstages	0.68 (0.60-0.78)		0.58 (0.45-0.75)		0.82 (0.72-0.94)
	Upstages	1.53 (1.13-2.07)		1.08 (1.02-1.91)		1.49 (1.09-2.03)
Response of N-stages ratio	Equal-stage	ref	< 0.0001	ref	0.2379	ref	< 0.0001
	N pCR	0.60 (0.49-0.73)		0.80 (0.56-1.14)		0.65 (0.54-0.78)
	Downstages	0.86 (0.69-1.08)		0.93 (0.61-1.43)		0.85 (0.68-1.07)
	Upstages	1.53 (1.32-1.78)		1.17 (0.88-1.56)		1.63 (1.40-1.90)
Response of AJCC-stages ratio	Equal-stage	ref	< 0.0001	ref	< 0.0001	ref	< 0.0001
	pCR	0.21 (0.13-0.34)		0.19 (0.08-0.48)		0.33 (0.23-0.47)
	Downstages	0.56 (0.48-0.65)		0.67 (0.51-0.89)		0.61 (0.52-0.70)
	Upstages	1.85 (1.56-2.18)		1.17 (0.84-1.62)		1.61 (1.36-1.90)

HR, hazard ratio; CI, confidence interval; AJCC, American Joint Committee on Cancer; LRR, locoregional recurrence; DM, distant metastasis; T-stages, primary breast diseases; N-stages, nodal diseases; T, tumor; N, nodal. All variables presented in Tables 1 and 2 were used in this multivariate analysis.