Table 1.

The role of overexpressed SLC7A11 in cancer

Tumor types	Characteristics
Acute myeloid leukemia [132]	Independent poor prognostic factor
Breast cancer [23,51,133]	Carcinogenesis, CSC state and biology, poor prognosis, therapeutic target
Ovarian cancer [134]	Independent risk prognostic factor for overall survival
Colorectal cancer [135]	Independent prognostic predictor of disease recurrence, depth of tumor invasion, lymph node metastasis and venous invasion
Non-small cell lung cancer (NSCLC) [136]	Increased tumor growth and development, advanced cancer stage, shorter 5-year survival
Prostate cancer [19]	Low survival rate, resistance to radiation therapy, increased tumor invasion and metastasis, decreased intracellular ROS and extracellular H2O2 levels, and value of the redox couples Cys/CySS
Hepatocellular carcinoma (HCC) [137-139]	Poor differentiation, advanced pathological stages, independent unfavorable prognostic factor for overall survival and disease-free survival, potential therapeutic target
Glioma [24,54]	Accelerated tumor growth, decreased migration and invasion, increased CSC-like phenotype and potential chemoresistance, complicated clinical course with peritumoral seizures, shorter overall survival
Melanoma [140]	Enhanced tumor proliferation and progression, larger xenograft tumors
Papillary thyroid carcinoma (PTC) [141]	Poor survival, higher mortality, advanced cancer stage
Oral cavity squamous cell carcinoma (SCC) [142]	Advanced T cell classification, perineural invasion, lymphovascular invasion, independent prognostic factor for poor recurrence-free survival, disease-specific survival, and overall survival