Table 2.

The associations of individual LTL-associated SNPs with the risks of recurrence and death

SNP ID	Chr.	Position	Gene	Allele*	SNP-LTL		SNP-Recurrence			SNP-Death
					EAF*	β*	β**	HR** (95% CI)	P value	β**	HR** (95% CI)	P value
rs11125529	2	54475866	ACYP2	A/C	0.14	0.07	-0.15	0.86 (0.69-1.08)	0.206	-0.14	0.87 (0.70-1.09)	0.222
rs6772228	3	58376019	PXK	T/A	0.94	0.04	-0.32	0.72 (0.52-1.02)	0.062	-0.02	0.98 (0.67-1.42)	0.901
rs10936599	3	169492101	TERC	C/T	0.75	0.10	-0.05	0.95 (0.81-1.12)	0.542	-0.16	0.85 (0.73-1.00)	0.047
rs7675998	4	164007820	NAF1	G/A	0.77	0.05	-0.16	0.85 (0.73-0.99)	0.043	-0.05	0.95 (0.81-1.12)	0.567
rs2736100	5	1286516	TERT	C/A	0.51	0.09	0.02	1.02 (0.89-1.17)	0.781	-0.02	0.98 (0.86-1.11)	0.724
rs9420907	10	105676465	OBFC1	C/A	0.13	0.14	-0.05	0.95 (0.78-1.15)	0.592	-0.16	0.85 (0.70-1.03)	0.101
rs3027234	17	8136092	CTC1	C/T	0.78	0.10	-0.09	0.91 (0.76-1.09)	0.316	-0.01	0.99 (0.84-1.18)	0.937
rs8105767	19	22215441	ZNF208	G/A	0.29	0.06	0.01	1.01 (0.88-1.17)	0.873	0.00	1.00 (0.87-1.15)	0.983
rs6028466	20	38129002	DHX35	A/G	0.06	0.06	-0.03	0.97 (0.73-1.29)	0.834	-0.02	0.98 (.075-1.29)	0.898
rs755017	20	62421622	ZBTB46	G/A	0.12	0.02	0.08	1.08 (0.89-1.31)	0.436	-0.10	0.91 (0.74-1.10)	0.321

^*Alleles are short allele/long allele. Short alleles are used as the reference allele and long allele as effect allele. EAF: effect allele frequency;

^*β estimates of SNP-LTL association were from published GWAS;

^**β estimates for SNP-recurrence and SNP-Survival were from this study.

^**Adjusted by age, smoking status, BMI, histology, stage, grade, and treatment.