TABLE 1.

Nonsynonymous SNPs of SARS-CoV-2 nsp12

Genomic locus	Gene locus	Amino acid change	Domain	No. of nonsynonymous SNPs
				Wave 1 (n = 1,026)	Wave 2 (n = 4,059)	Total (n = 5,085)
13446	C3T	A1V	N terminus		2	2
13448	G5A	D2N	N terminus	1		1
13487	C44T	A15V	N terminus		138	138
13501	C58T	P20S	N terminus		1	1
13514	G71A	G24D	N terminus		3	3
13517	C74T	T25I	N terminus		4	4
13520	G77A	S26N	N terminus		1	1
13523	C80T	T27I	N terminus		1	1
13526	A83C	D28A	N terminus		1	1
13564	G121A	V41I	B hairpin		1	1
13568	C125T	A42V	B hairpin	1		1
13571	G128T	G43V	B hairpin	1		1
13576	G133T	A45S	B hairpin		12	12
13617	G174T	K58N	NiRANa		1	1
13618	G175T	D59Y	NiRAN		24	24
13620	C177G	D59E	NiRAN		1	1
13627	G184T	D62Y	NiRAN	1		1
13661	G218A	R73K	NiRAN		1	1
13667	C224T	T75I	NiRAN		2	2
13694	C251T	T84I	NiRAN		1	1
13712	A269G	K90R	NiRAN		1	1
13726	G283A	V95I	NiRAN		1	1
13730	C287T	A96V	NiRAN	2	2	4
13762	G319C	G107R	NiRAN		1	1
13774	C331A	P111T	NiRAN		1	1
13774	C331T	P111S	NiRAN		15	15
13777	C334T	H112Y	NiRAN		1	1
13790	A347G	Q116R	NiRAN		2	2
13835	G392T	R131M	NiRAN		1	1
13858	G415T	D139Y	NiRAN		3	3
13862	C419T	T140I	NiRAN	1	5	6
13868	A425G	K142R	NiRAN	1		1
13897	G454T	D152Y	NiRAN		4	4
13901	A458G	D153G	NiRAN		2	2
13957	C514T	R172C	NiRAN		2	2
13963	T520C	Y174H	NiRAN		1	1
13966	G523A	A175T	NiRAN		1	1
13975	G532T	G178C	NiRAN		4	4
13984	G541A	V181I	NiRAN		1	1
13994	C551T	A184V	NiRAN		8	8
14104	T661C	F221L	NiRAN	2		2
14109	A666G	I222M	NiRAN	1		1
14120	C677T	P226L	NiRAN		2	2
14185	A742G	R248G	NiRAN		1	1
14187	G744T	R248S	NiRAN		1	1
14188	G745A	A249T	NiRAN		1	1
14225	C782A	T261K	Interface		4	4
14230	C787T	P263S	Interface		1	1
14233	T790C	Y264H	Interface		1	1
14241	G798T	K266N	Interface		1	1
14290	G847T	D283Y	Interface		1	1
14335	G892T	V298F	Interface		8	8
14362	C919A	L307M	Interface		2	2
14371	G928C	A310P	Interface	1		1
14396	C953T	T318I	Interface		1	1
14398	G955T	V319L	Interface		1	1
14407	C964T	P322S	Interface		2	2
14408	C965T	P322L	Interface	843	4,050	4,893
14500	G1057T	V353L	Interface		5	5
14536	C1093T	L365F	Interface		1	1
14557	G1114T	V372L	Fingers		4	4
14584	G1141T	A381S	Fingers		1	1
14585	C1142T	A381V	Fingers		10	10
14593	G1150A	G384S	Fingers	1		1
14657	C1214T	A405V	Fingers		1	1
14708	C1265T	A422V	Fingers		1	1
14747	A1304G	E435G	Fingers		2	2
14768	C1325T	A442V	Fingers		21	21
14786	C1343T	A448V	Fingers	3	6	9
14821	C1378T	P460S	Fingers		1	1
14829	G1386T	M462I	Fingers		59	59
14831	G1388T	C463F	Fingers		3	3
14857	G1414T	V472F	Fingers		1	1
14870	A1427G	D476G	Fingers		5	5
14874	G1431T	K477N	Fingers	1		1
14912	A1469G	N490S	Fingers	1	1	2
14923	G1480A	V494I	Fingers		2	2
14980	C1537T	L513F	Fingers	1	1	2
14990	A1547G	D516G	Fingers		1	1
15006	G1563C	E521D	Fingers	2	3	5
15016	G1573T	A525S	Fingers		3	3
15026	C1583T	A528V	Fingers	5	1	6
15037	C1594T	R532C	Fingers		1	1
15100	G1657C	A553P	Fingers		1	1
15101	C1658T	A553V	Fingers		1	1
15124	A1681G	I561V	Fingers		2	2
15202	G1759C	V587L	Palm		7	7
15211	A1768G	T590A	Palm		1	1
15226	G1783A	G595S	Palm		1	1
15243	G1800T	M600I	Palm	71	4	75
15251	C1808G	T603S	Palm		1	1
15257	A1814G	Y605C	Palm		1	1
15260	G1817A	S606N	Palm		1	1
15327	G1884T	M628I	Fingers	3	1	4
15328	C1885T	L629F	Fingers	1		1
15334	A1891G	I631V	Fingers		1	1
15341	C1898T	A633V	Fingers		1	1
15352	C1909T	L637F	Fingers		1	1
15358	C1915T	R639C	Fingers		1	1
15362	A1919G	K640R	Fingers		1	1
15364	C1921G	H641D	Fingers	1		1
15368	C1925T	T642I	Fingers	1		1
15380	G1937T	S646I	Fingers	1		1
15386	C1943T	S648L	Fingers		2	2
15391	C1948T	R650C	Fingers		1	1
15406	G1963T	A655S	Fingers		3	3
15407	C1964T	A655V	Fingers	1		1
15436	A1993G	M665V	Fingers		2	2
15438	G1995T	M665I	Fingers		24	24
15452	G2009T	G670V	Fingers		28	28
15487	G2044C	G682R	Palm		1	1
15497	C2054A	T685K	Palm		1	1
15572	A2129G	D710G	Palm		1	1
15596	A2153G	Y718S	Palm	2		2
15619	C2176T	L726F	Palm	1		1
15638	G2195A	R732K	Palm	1		1
15640	A2197G	N733D	Palm	1		1
15640	A2197T	N733Y	Palm	1		1
15655	A2212G	T738A	Palm		2	2
15656	C2213T	T738I	Palm		2	2
15658	G2215A	D739N	Palm		2	2
15664	G2221A	V741M	Palm		1	1
15715	T2272C	S758P	Palm		1	1
15760	G2317A	G773S	Palm	1		1
15761	G2318A	G773D	Palm		1	1
15827	A2384G	E795G	Palm	1		1
15848	C2405T	T802I	Palm		1	1
15850	G2407T	D803Y	Palm		1	1
15853	C2410T	L804F	Palm		2	2
15878	G2435T	C812F	Palm		1	1
15886	C2443T	H815Y	Palm		1	1
15906	G2463T	Q821H	Thumb	1	1	2
15908	G2465T	G822V	Thumb		1	1
15979	A2536G	I846V	Thumb	4		4
16045	C2602T	L868F	Thumb		1	1
16084	C2641T	H881Y	Thumb		1	1
16148	A2705G	Y902C	Thumb		1	1
16163	C2720T	T907I	Thumb		45	45
16178	C2735T	S912L	Thumb		2	2
16192	C2749T	P917S	Thumb		80	80

^aNiRAN, nucleotidyl transferase domain.