Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 22;11:578003. doi: 10.3389/fneur.2020.578003

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Park, Chang, Kim and Lee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Ly6C⁺ pro-inflammatory monocyte conversion and contribution to ischemic stroke recovery in vivo. After the onset of ischemic stroke, DAMP released by dying neurons activates microglia and astrocytes. C-C motif ligand 2 (CCL2) and C-C motif ligand 5 (CCL5), which are secreted by activated microglia and astrocytes, induce the infiltration of Ly6C⁺ pro-inflammatory monocytes into the injury site. Infiltrating Ly6C⁺ monocytes convert into M2 macrophages depending on the presence of Nr4a1 (MONO to MØ). In addition, activated microglia are polarized into M2 macrophages, releasing anti-inflammatory cytokines, resulting in ischemic stroke recovery. However, whether the conversion of Ly6C⁺ pro-inflammatory monocytes to Ly6C⁻ anti-inflammatory monocytes (MONO to MONO) occurs in the brain, attenuating neuroinflammation following ischemic stroke, remains unclear.