Table 1.
miRNAs-related monocyte heterogeneity.
| Monocyte functions | Pro-inflammatory | Anti-inflammatory | Anti-inflammatory | |
|---|---|---|---|---|
| 1. Heterogeneity of monocyte subsets related with miRNA expression in basal condition | ||||
| Monocyte phenotype | Human | CD14++CD16− | CD14+CD16+ | CD14+CD16++ |
| Mouse | Ly6C+CCR2highCX3CR1low | - | Ly6C−CCR2lowCX3CR1high | |
| Expression level of miRNAs | miRNA-17 miRNA-18a/b miRNA-19b miRNA-20b miRNA-106a miRNA-432 miRNA-150 miRNA-132 miRNA-146a miRNA-342-3p miRNA-19a miRNA-21 |
High High High High High Low High Low Low Low Low Low |
ßLow Moderate Moderate Low Low Moderate Low Moderate Moderate Moderate Moderate Moderate |
Low Low Low Low Low High High High High High High High |
| 2. Implications related to the role of miRNAs in monocyte subsets | ||||
| miRNA-21 deletion | Increase of pro-inflammatory response | |||
| miRNA-19a knockdown | Inhibition of CD16− monocytes movement | |||
| miRNA-146a deletion | Dysregulation of myeloproliferation and myelodifferentiation of HSCs | |||
| Dysregulation of pro-inflammatory response | ||||
| miRNA-150 deletion | Decrease of Ly6C− monocyte by overexpression of Tet3 gene | |||
| miRNA-432 overexpression | Increase of CD16− monocyte apoptosis | |||