Table 3.

Current ischemic stroke therapeutics targeting anti-inflammation.

Therapeutics	Role(s)	Effect(s) on stroke
Aspirin	- Non-selective cyclooxygenase inhibitor	- Decrease the accumulation of macrophages - Delays the onset of ischemic stroke
Rosuvastatin	- Lowers low-density lipoprotein cholesterol - Lowers high-sensitivity CRP levels	- Attenuate the expression of inflammatory biomarkers: MCP-1, IL-1β TNF-α, TGF-β1, p-selectin
Thiazolidinediones	- PPARγ agonists	- Suppress the cyclooxygenase-2 expression - Inhibit the infiltration of macrophages - Decrease the expression level of MCP-1 and TNF-α - Promote the PPARγ DNA binding
Minocycline	- Semisynthetic tetracycline antibiotic	- Reduce the microglia/macrophage activation - Improves the neurological outcome