Table 5.
Genes significant for alternative splicing (AS) in the (A) male and (B) female cohorts for all ischemic stroke (IS) and the three main causes of stroke.
|
Gene symbol |
Affymetrix transcript clusters |
AS (Dx-All IS) p-value |
AS (Dx-CE) FDR |
AS (Dx-LVD) FDR |
AS (Dx-SVD) FDR |
|---|---|---|---|---|---|
| A. GENES SIGNIFICANT FOR AS IN THE MALE COHORT | |||||
| ADD1 | TC04000039 | 2.81E-09 | 2.84E-05 | 2.62E-03 | |
| ALDH2 | TC12003212 | 1.84E-05 | |||
| ALOX5AP | TC13000100 | 4.25E-03 | |||
| APOL2 | TC22000702 | 2.38E-02 | |||
| CDKN2A | TC09000964 | 4.01E-02 | |||
| CYP4A11 | TC01002625 | 6.98E-15 | |||
| CYP4F2 | TC19001261 | 1.82E-06 | |||
| DDAH1 | TC01002829 | 2.79E-03 | |||
| EPHX2 | TC08000208 | 4.81E-04 | |||
| F13B | TC01003661 | 9.37E-03 | |||
| F2 | TC11000401 | 2.29E-02 | |||
| FGB | TC04000777 | 9.37E-03 | |||
| GP1BA | TC17000056 | 2.92E-08 | 2.28E-04 | ||
| HDAC9 | TC07000116 | 1.09E-14 | 1.40E-02 | ||
| IL1A | TC02002218 | 1.33E-03 | |||
| IMPA2 | TC18000060 | 3.82E-04 | |||
| ITGA2B | TC17001581 | 4.03E-04 | 1.00E-09 | ||
| ITGB3 | TC17002878 | 2.40E-04 | 1.77E-08 | ||
| LDLR | TC19000191 | 1.43E-03 | |||
| LPA | TC06002281 | 1.93E-04 | 2.15E-02 | 4.57E-03 | |
| LPAL2 | TC06002280 | 4.20E-05 | 4.51E-03 | ||
| MTHFR | TC01002202 | 2.96E-03 | |||
| NINJ2 | TC12001083 | 2.40E-08 | 2.01E-19 | 3.90E-02 | |
| NOS1 | TC12002014 | 1.77E-02 | |||
| NPY | TC07000153 | 4.57E-03 | |||
| PCSK9 | TC01000675 | 3.87E-04 | 1.77E-02 | ||
| PDGFC | TC04001673 | 6.64E-03 | 1.77E-02 | ||
| PLPP3 | TC01002701 | 9.37E-03 | |||
| PON3 | TC07003364 | 4.81E-04 | |||
| PTGIS | TC20000927 | 2.65E-04 | |||
| SGK1 | TC06002126 | 2.17E-02 | |||
| SH2B3 | TC12000868 | 8.39E-07 | |||
| SMARCA4 | TC19000190 | 1.83E-12 | |||
| SORT1 | TC01002954 | 3.66E-05 | 3.90E-02 | ||
| WNK1 | TC12000010 | 2.07E-05 | 1.02E-07 | 5.25E-04 | |
| ZFHX3 | TC16001259 | 2.43E-03 | 2.17E-02 | ||
| B. GENES SIGNIFICANT FOR AS IN THE FEMALE COHORT | |||||
| ADD1 | TC04000039 | 7.88E-05 | |||
| ALDH2 | TC12000871 | 1.99E-02 | |||
| ALDH2 | TC12003212 | 2.39E-02 | 2.36E-02 | ||
| EPHX2 | TC08000208 | 2.43E-21 | |||
| F13A1 | TC06001246 | 3.36E-14 | 2.34E-05 | ||
| F13B | TC01003661 | 3.70E-04 | |||
| F5 | TC01003498 | 1.29E-05 | 1.04E-19 | 3.45E-15 | |
| GP1BA | TC17000056 | 2.01E-09 | |||
| HDAC9 | TC07000116 | 2.13E-05 | |||
| IL1A | TC02002218 | 9.66E-03 | |||
| ITGA2B | TC17001581 | 5.97E-04 | |||
| ITGB3 | TC17002878 | 2.61E-02 | |||
| LDLR | TC19000191 | 2.05E-04 | 2.42E-06 | ||
| MTHFR | TC01002202 | 2.42E-03 | 4.42E-02 | 1.28E-03 | |
| NAA25 | TC12001977 | 7.22E-07 | |||
| PDE4D | TC05001389 | 2.66E-15 | 2.16E-02 | ||
| PEMT | TC17001188 | 4.42E-03 | |||
| PON1 | TC07003363 | 7.76E-06 | 1.28E-03 | ||
| PON3 | TC07003364 | 1.49E-07 | |||
| PRKCH | TC14000371 | 1.60E-13 | 6.84E-49 | ||
| SMARCA4 | TC19000190 | 9.41E-08 | 5.74E-12 | 1.12E-03 | |
| SUPT3H | TC06001765 | 1.70E-06 | |||
| ZC3HC1 | TC07001860 | 3.27E-02 | |||
| ZFHX3 | TC16001259 | 9.37E-03 | |||
| ZPR1 | TC11002324 | 3.27E-02 | |||
Significance: false discovery rate (FDR) <0.3. Bold font indicates sex-specific alternatively spliced genes. Italicized font indicates AS common between sexes, but which differ between stroke cause. CE, cardioembolism; LVD, large vessel disease; SVD, small vessel disease/lacunar.