Figure 3.

Influence of post-sample session local muscimol-induced inactivation of the CA1 or PRh on test session object discrimination depends on strength of object memory training. (A) Mice that achieved the strong object memory training criterion and then received an intra-CA1 infusion of muscimol exhibited significant impairment of object discrimination relative to the intra-CA1 saline-treated mice during the test session. Mice that achieved the strong object memory training criterion and then received an intra-PRh infusion of muscimol exhibited test session object discrimination that was comparable to that of intra-PRh saline-treated mice. (B) Mice that achieved the weak object memory training criterion and then received intra-CA1 muscimol exhibited object discrimination that was comparable to that of intra-CA1 saline-treated mice. Mice that achieved the weak object memory training criterion and then received intra-PRh muscimol exhibited significant impairment of object discrimination relative to the intra-PRh saline-treated mice. Note that the overall object discrimination performance of mice that received weak object memory training was significantly lower than that of mice that received strong object memory training. *P < 0.05 vs. vehicle group; mean ± SEM. Individual data points are represented by the small black filled circles superimposed over the respective group mean bar.